Fresh analysis reveals that people who discontinue popular slimming jabs like semaglutide or tirzepatide may regain lost weight far faster than those who stop conventional lifestyle plans.
Findings released in a prominent medical journal points out that while overweight individuals frequently drop a large proportion of their total mass while undergoing treatment, the mass returns at an average rate of 0.8 kg per month upon discontinuation.
"People purchasing such treatments should be cognizant of the potential of quick rebound weight gain when the therapy concludes," stated expert Dr. Susan Jebb.
This pace of recovery suggests a return to original weight within about one and a half years.
Weighing Therapies
The research, which looked at dozens of studies involving over 9,000 of patients, compared the effects of the injectable medications with other pills.
The team emphasize that people who shed pounds through diet and exercise usually see a slower creep back—perhaps 0.1 kg a month—after stopping.
Explaining the Quick Regain
Nutrition scientists believe the mechanism of the injections is key to understanding the amplified regain.
These medications mimic a natural hormone called GLP-1, which helps regulate appetite.
"Sustained high doses of the hormone levels several times higher than normal could lead to the body to produce less of its endogenous hormone, and could diminish sensitivity to its actions," explained Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication means appetite is unsuppressed, making binge eating far more likely."
An Ongoing Disease?
Health authorities suggest the injections for people with obesity-related health risks, alongside recommended diet and exercise modifications.
Many experts argue that, given the likelihood of weight regain, the therapy might need to be long-term.
This perspective is echoed by pharmaceutical companies, who say that the findings "highlight the persistent nature of obesity," similar to managing diseases like hypertension.
Patient Accounts
Users who have stopped the jabs explain a intense resurgence of hunger.
"It felt as if a switch that goes on and you become extremely hungry," described one woman.
The struggle is compounded if users have not developed sustainable lifestyle or habit changes during therapy.
Widespread Use
Figures indicate that millions of people in the UK have used weight-loss jabs in the last 12 months, with desire being substantial.
- Adoption is higher among women compared to males.
- The middle-aged demographic shows the highest level of interest.
- Many access the medications through private prescriptions rather than public health services.
Finally, clinicians emphasize that while the jabs are effective agents for shedding pounds, they are not a permanent solution and lasting health benefits relies on ongoing lifestyle changes.
